Home Products Links Contact Us Technical Support News

Herbs and epilepsy

Hemp CBD and CBD oil are currently used for treating epilepsy.

Prescription CBD oil

The British company GW industries obtained FDA approval in 2018 as a drug to treat two types of childhood epilepsies. The drug Epidilox is being described as Pharmaceutical grade CDB oil. The cost for a single patient is predicted at about 32,000 dollars a year or about 2700 dollars a month. GW Industries obtained FDA approval after clinical trials of 571 patients. Of these Dravet syndrome and Lennox-Gastaut Syndrome were trialed and both had a substantial reduction in seizures.

In their trials, EPIDIOLEX, was added to the patients current treatment and for a 20 kg, or 50 pound child, the daily dose would be 400 mg.

The results showed that for half the patients, Epidiolex reduced seizure frequency by 50%, and over 6% of the patients became seizure free.

Epidiolex is 98% CBD oil.

The credit for discovery of CBD for seizures goes to Charlotte Figi and her family. In this now famous case, Charlotte was helped with a CBD oil that is now produced under the name Charlotte's Web.

Charlotte's Web is sold at their website and a non profit group has supported payments to over 1300 patients. They report a similar number to Epidiolex of 50% reduction in seizures for 50% of patients and report 10% are seizure free.

Recommendations

Hemp CBD oil is certainly worth a try for a patient with epilepsy. It can have remarkable results with few side effects. But it is likely to help only half the people who try it. But 10% of the people who try it might become seizure free.

Introduced in the Netherlands in 2014, Bedrolite® is the brand name for the cultivar Cannabis sativa L. ‘Rensina’. a CBD product, with less than 1% THC and 9% CBD. The virtual absence of THC means it does not have psychoactive properties. Bedrolite® is the preferred choice of patients with severe, intractable (untreatable) forms of epilepsy in the Netherlands.

Growing Live Plant Hemp CBD

Peggy Bradley is treating her epilepsy with fresh hemp CBD leaf, and not the CBD oil. This amounts to picking two or three leaves from a live hemp CBD plant.

Anti-seizure Tea

Recipe
Two to three hemp CBD fresh leaf
Three springs stevia
Moringa oleifera 3 fresh leaf
1 pat of butter

Place the ingredients in a teacup and microwave for 20 seconds to melt butter. The CBDA is soluble in fats.
Then soymilk and water and microwave for one minute. Let steep for five minutes and drink.

Peggy uses at least two cups of tea a day.

The hemp CBD that is used for this has an analysis of 4.8% CBDA in the wet weight. The CBDA in the cup is about 20 mg and so two cups a day is about 40 mg. According to the GW research, an effective dose is between 12 to 123 mg a day.

Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? A review of CBDA and CBD on seizures

Use of cannabinoids in the treatment of epilepsy This is a patent claim listed by GW Industries showing CBDA is more bioavailable and more effective than CBD in treating some forms of epilepsy. Part of the statements are

Claim [0005] Intractable or treatment-resistant epilepsy was defined in 2009 by the International League Against Epilepsy (ILAE) as "failure of adequate trials of two tolerated and appropriately chosen and used AED schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom" (Kwan et al. , 2009).

Claim [0045] As the cannabinoid CBDA is more bioavailable than its neutral form CBD, it is likely that a far lower dose of CBDA will be required in comparison with CBD when treating the same indication. For example providing a human with a dose of 20 mg/kg of CBD to treat epilepsy may be effective, whereas the dose of CBDA required may be a log fold lower.

Claim [0089] Notably, in three of the four parameters measured CBDA produced significant anticonvulsant effects and were statistically more effective than CBD at an equivalent dose.

Claim [0090] For example, Panel A of Figure 2 describes the effect of CBDA and CBD on the seizure severity. The median score for the maximum seizure severity that the animals experienced with 100mg/kg CBDA was 3 (Table 6 - fully developed bilateral forelimb clonus, with righting reflex preserved) and the median for 100 mg/kg CBD was 5 (Table 6 - fully developed tonic-clonic seizure, with righting reflex lost). This shows that CBDA was able to prevent the animals from suffering from more severe types of seizure than CBD was.

OVERALL CONCLUSION

[00137] CBDA has anticonvulsant effects in a mammalian model of epilepsy and is effective in treating generalised seizures, more particularly, tonic-clonic seizures. Indeed, this compound appears more effective than CBD in many of the parameters tested.

[00138] CBDA is significantly more potent than CBD upon growth of D. discoideum; and CBDA acts more quickly and is more bioavailable than CBD.

[00139] These findings are of great significance as they demonstrate that CBDA offers an alternative anti-convulsant to CBD. The finding that CBDA is more potent and more bioavailable than CBD means that a smaller daily dose of the active ingredient may be used in the treatment of epilepsy. Doses of less than 400mg and possibly doses of as little as from 1 mg - 100mg, might be used to treat human subjects. In this regard, a typical adult patient might weigh 60kg and thus, a daily dose for such a patient might be from 0.016mg/kg to 1.6mg/kg.

Moringa in treating epilepsy

Moringa oleifera, a tropical tree or bush, is an ancient treatment for epilepsy.

Now being used in several trials, the results look very promising.

Moringa and Epilepsy treatment summary from NIH.

Leucas martinicensis

Article on botanicals and Epilepsy

IS IT LEGAL

The 2018 USA Farm Bill removed hemp from a schedule 1 product. This paves the way for making hemp a legal product in the states. However, state law may still make hemp illegal and so you need to check with your state and perhaps your local area.

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Copyright © 2019 Medicinal Herb Resource Center